You asked:

is melissa gilbert related to sara gilbert

Yes
Melissa Gilbert
Melissa Gilbert

Melissa Gilbert (born 1964), the American actor & activist

Sara Gilbert
Sara Gilbert

Sara Gilbert (born Sara Rebecca Abeles on January 29, 1975 in Santa Monica, California), the American actress best known for her longtime role as Darlene Conner-Healy from 1988-1997 in the U.S. sitcom Roseanne

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